Anti-Integrin Alpha-IIb (GPIIb, CD41), Beta Propeller Domain [MBC 290.5] Antibody
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This IgG1 mouse monoclonal (MBC 290.5) was generated against human glycoprotein IIb and is specific for beta propeller domain of human glycoprotein IIb.
Highlights:
- Reacts with human glycoprotein IIb
- Suitable for Flow Cytometry
Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin.
This IgG1 mouse monoclonal (MBC 290.5) was generated against human glycoprotein IIb and is specific for beta propeller domain of human glycoprotein IIb.
Highlights:
- Reacts with human glycoprotein IIb
- Suitable for Flow Cytometry
Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin.
Specifications
| Product Type: | Antibody |
| Accession ID: | P08514 |
| Antigen: | Glycoprotein IIb |
| Isotype: | IgG1 |
| Clonality: | Monoclonal |
| Clone Name: | MBC 290.5 |
| Reactivity: | Human |
| Immunogen: | Beta propeller domain |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Method Used to Determine Concentration: | BCA |
| Buffer: | PBS |
| Tested Applications: | Flow Cytometry (0.02 mg/mL) |
| Concentration: | 1mg/mL |
| Storage: | -20C |
| Shipped: | Cold packs |
Research
| Antibody | Domain |
| Anti-Integrin Alpha-IIb (GPIIb, CD41) [MBC 132.1] | Glycoprotein IIb |
| Anti-Integrin Alpha-IIb (GPIIb, CD41), Beta Propeller Domain [MBC 290.5] | Beta propeller |
| Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-1 Domain [MBC 370.2] | Calf 1 |
| Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-2 Light Chain [MBC 314.5] | Calf 2- light chain |
| Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 319.4] | EGF repeats |
| Anti-Integrin Beta 3 (GPIIIa, CD61), PSI Domain [AP-3] | PSI/Hybrid amino acids 50-62 |
| Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 322.8] | EGF repeats |
| Anti-Integrin Beta 3 (GPIIIa, CD61), PSI Domain [AP-5] | PSI amino acids 1-6 |
| Anti-Glycoprotein GPIIIa/GPIIb Complex [AP-2] | Beta 1 |
Provider
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin
References
- Padmanabhan A, Jones CG, Bougie DW, Curtis BR, McFarland JG, Wang D, Aster RH. Heparin-independent, PF4-dependent binding of HIT antibodies to platelets: implications for HIT pathogenesis. Blood. 2015 Jan 1;125(1):155-61. doi: 10.1182/blood-2014-06-580894. Epub 2014 Oct 23.
If you publish research with this product, please let us know so we can cite your paper.
