Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-1 Domain [MBC 370.2] Antibody
![Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-1 Domain [MBC 370.2] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/915_200120200126269140.jpg "Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-1 Domain [MBC 370.2] Antibody")
This IgG1 mouse monoclonal (MBC 370.2) was generated against human glycoprotein IIb and is specific for calf-1 domain of human glycoprotein IIb when integrin is in a complex with RDG containing peptides.
Highlights:
- Reacts with human glycoprotein IIb
- Ligand Induced Binding Site (LIBS) antibody
- Suitable for Flow Cytometry
Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin.
This IgG1 mouse monoclonal (MBC 370.2) was generated against human glycoprotein IIb and is specific for calf-1 domain of human glycoprotein IIb when integrin is in a complex with RDG containing peptides.
Highlights:
- Reacts with human glycoprotein IIb
- Ligand Induced Binding Site (LIBS) antibody
- Suitable for Flow Cytometry
Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin.
Specifications
| Product Type: | Antibody |
| Antigen: | Glycoprotein IIb |
| Accession ID: | P08514 |
| Isotype: | IgG1 |
| Clonality: | Monoclonal |
| Clone Name: | MBC 370.2 |
| Reactivity: | Human |
| Immunogen: | Calf-1 domain |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Method Used to Determine Concentration: | BCA |
| Buffer: | PBS |
| Tested Applications: | Flow Cytometry (0.01 mg/mL) |
| Concentration: | 1mg/mL |
| Storage: | -20C |
| Shipped: | Cold packs |
Research
| Antibody | Domain |
| Anti-Integrin Alpha-IIb (GPIIb, CD41) [MBC 132.1] | Glycoprotein IIb |
| Anti-Integrin Alpha-IIb (GPIIb, CD41), Beta Propeller Domain [MBC 290.5] | Beta propeller |
| Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-1 Domain [MBC 370.2] | Calf 1 |
| Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-2 Light Chain [MBC 314.5] | Calf 2- light chain |
| Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 319.4] | EGF repeats |
| Anti-Integrin Beta 3 (GPIIIa, CD61), PSI Domain [AP-3] | PSI/Hybrid amino acids 50-62 |
| Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 322.8] | EGF repeats |
| Anti-Integrin Beta 3 (GPIIIa, CD61), PSI Domain [AP-5] | PSI amino acids 1-6 |
| Anti-Glycoprotein GPIIIa/GPIIb Complex [AP-2] | Beta 1 |
Provider
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin
References
- Chen Y, Ju LA, Zhou F, Liao J, Xue L, Su QP, Jin D, Yuan Y, Lu H, Jackson SP, Zhu C. An integrin α(IIb)β(3) intermediate affinity state mediates biomechanical platelet aggregation. Nat Mater. 2019 Mar 25. View Article
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