Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 319.4] Antibody
![Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 319.4] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/919_200120200126279180.jpg "Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 319.4] Antibody")
This IgG2b mouse monoclonal (MBC 319.4) was generated against human glycoprotein IIIa and is specific for the EGF repeats domain of human glycoprotein IIIa (GPIIIa; CD61) when integrin is in a complex with RDG containing peptides.
Highlights:
- Reacts with human glycoprotein IIIa
- Ligand Binding Site (LIBS) antibody
- Suitable for Flow Cytometry
Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin.
This IgG2b mouse monoclonal (MBC 319.4) was generated against human glycoprotein IIIa and is specific for the EGF repeats domain of human glycoprotein IIIa (GPIIIa; CD61) when integrin is in a complex with RDG containing peptides.
Highlights:
- Reacts with human glycoprotein IIIa
- Ligand Binding Site (LIBS) antibody
- Suitable for Flow Cytometry
Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin.
Specifications
| Product Type: | Antibody |
| Antigen: | Glycoprotein IIIa |
| Accession ID: | P05106 |
| Isotype: | IgG2b |
| Clonality: | Monoclonal |
| Clone Name: | MBC 319.4 |
| Reactivity: | Human |
| Immunogen: | EGF repeats |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Method Used to Determine Concentration: | BCA |
| Buffer: | PBS |
| Tested Applications: | Flow Cytometry (0.01 mg/mL) |
| Concentration: | 1 mg/mL |
| Storage: | -20C |
| Shipped: | Cold packs |
Research
| Antibody | Domain |
| Anti-Integrin Alpha-IIb (GPIIb, CD41) [MBC 132.1] | Glycoprotein IIb |
| Anti-Integrin Alpha-IIb (GPIIb, CD41), Beta Propeller Domain [MBC 290.5] | Beta propeller |
| Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-1 Domain [MBC 370.2] | Calf 1 |
| Anti-Integrin Alpha-IIb (GPIIb, CD41), Calf-2 Light Chain [MBC 314.5] | Calf 2- light chain |
| Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 319.4] | EGF repeats |
| Anti-Integrin Beta 3 (GPIIIa, CD61), PSI Domain [AP-3] | PSI/Hybrid amino acids 50-62 |
| Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 322.8] | EGF repeats |
| Anti-Integrin Beta 3 (GPIIIa, CD61), PSI Domain [AP-5] | PSI amino acids 1-6 |
| Anti-Glycoprotein GPIIIa/GPIIb Complex [AP-2] | Beta 1 |
Provider
From the laboratory of Richard H. Aster, MD, PhD, Blood Center of Wisconsin
References
- Chen Y, Ju LA, Zhou F, Liao J, Xue L, Su QP, Jin D, Yuan Y, Lu H, Jackson SP, Zhu C. An integrin α(IIb)β(3) intermediate affinity state mediates biomechanical platelet aggregation. Nat Mater. 2019 Mar 25. View Article
If you publish research with this product, please let us know so we can cite your paper.
