Wild-type protective antigen (PA).
Anthrax toxin is a three-protein exotoxin secreted by virulent strains of the bacterium, Bacillus anthracis, the causative agent of anthrax. Anthrax toxin is composed of a cell-binding protein, known as protective antigen (PA), and two enzyme components, called edema factor (EF) and lethal factor (LF). Anthrax is caused by B. anthracis, a spore-forming, Gram positive, rod-shaped bacterium. The lethality of the disease is caused by the bacterium's two principal virulence factors: the polyglutamic acid capsule, which is anti-phagocytic, and the tripartite protein toxin, called anthrax toxin.
From the laboratory of Stephen H. Leppla, PhD, National Institute of Allergy and Infectious Diseases/NIH.
Read about how this product was utilized by Absolute Antibody to validate their, Recombinant Engineered Antibodies Against Anthrax.
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Product Type: | Protein |
Name: | Wild-type |
Alternative Name(s): | PAWT |
Accession ID: | P13423 |
Strain: | Expressed in avirulent engineered B. anthracisstrain BH480 |
Format: | Purified protein (liquid) |
Purity: | Hydroxyapatite Chromatography |
Buffer: | 5 mM Hepes pH 7.5, 0.50 mM EDTA |
Concentration: | 7.26mg/mL |
Storage: | -80C |
Shipped: | Dry ice |
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