The L687A mutant protective antigen (PA) binds preferentially to the CMG2 receptor vs. the TEM8 receptor.
Anthrax toxin is a three-protein exotoxin secreted by virulent strains of the bacterium, Bacillus anthracis, the causative agent of anthrax. Anthrax toxin is composed of a cell-binding protein, known as protective antigen (PA), and two enzyme components, called edema factor (EF) and lethal factor (LF). Anthrax is caused by B. anthracis, a spore-forming, Gram positive, rod-shaped bacterium. The lethality of the disease is caused by the bacterium's two principal virulence factors: the polyglutamic acid capsule, which is anti-phagocytic, and the tripartite protein toxin, called anthrax toxin.
From the laboratory of Stephen H. Leppla, PhD, National Institute of Allergy and Infectious Diseases/NIH.
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Product Type: | Protein |
Name: | L678A |
Alternative Name(s): | PA L687A |
Accession ID: | P13423 |
Strain: | Expressed in avirulent engineered B. anthracisstrain BH445 |
Format: | Purified protein (liquid) |
Purity: | Q-Sepharose Ion Exchange Chromatography |
Buffer: | 5 mM Hepes pH 7.5, 0.50 mM EDTA |
Concentration: | 6.24mg/mL |
Storage: | -80C |
Shipped: | Dry ice |
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