Anti-Tumor Necrosis Factor (TNF) [6H4] Antibody
![Anti-Tumor Necrosis Factor (TNF) [6H4] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/2006_2001202001271020050.jpg "Anti-Tumor Necrosis Factor (TNF) [6H4] Antibody, 100ug")
This mouse IgG2b monoclonal antibody was generated against equine tumor necrosis factor (TNF) protein and is specific for equine TNF.
Highlights:
- Reacts with equine TNF
- Has the ability to neutralize ETNFa and rHTNFa
- Some cross-reactivity observed with rHTNFa. None with nETNFß, nMTNFa, rMTNFß and rPTNFa
- Useful tool for the development of therapeutic agents against diseases associated with production of equine TNFa, such as Gram-negative infections, neonatal sepsis and auto-immune disorders
- Recommended for Western Blot and ELISA applications
Tumor necrosis factor is a cell signaling protein or cytokine that is involved in inflammation, and specifically one of the proteins in the acute phase reaction. TNF is produced mainly by macrophages but other white cells too. Some of its roles are to induce fever, apoptotic cell death, inhibit tumorigenesis and inflammation. Diseases associated with dysregulation of TNF production include inflammatory bowel disease (IBD), Psoriasis, Alzheimer's and cancer.
From the laboratory of Royal A. McGraw, University of Georgia.
Part of The Investigator's Annexe program.
This mouse IgG2b monoclonal antibody was generated against equine tumor necrosis factor (TNF) protein and is specific for equine TNF.
Highlights:
- Reacts with equine TNF
- Has the ability to neutralize ETNFa and rHTNFa
- Some cross-reactivity observed with rHTNFa. None with nETNFß, nMTNFa, rMTNFß and rPTNFa
- Useful tool for the development of therapeutic agents against diseases associated with production of equine TNFa, such as Gram-negative infections, neonatal sepsis and auto-immune disorders
- Recommended for Western Blot and ELISA applications
Tumor necrosis factor is a cell signaling protein or cytokine that is involved in inflammation, and specifically one of the proteins in the acute phase reaction. TNF is produced mainly by macrophages but other white cells too. Some of its roles are to induce fever, apoptotic cell death, inhibit tumorigenesis and inflammation. Diseases associated with dysregulation of TNF production include inflammatory bowel disease (IBD), Psoriasis, Alzheimer's and cancer.
From the laboratory of Royal A. McGraw, University of Georgia.
Part of The Investigator's Annexe program.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Antigen: | Tumor Necrosis Factor (TNF) |
| Accession ID: | P01375 |
| Isotype: | IgG2b |
| Clonality: | Monoclonal |
| Clone Name: | 6H4.E1 |
| Reactivity: | Equine |
| Immunogen: | Protein |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB and ELISA |
| Storage: | -20C |
| Shipped: | Cold packs |
- Su X, Morris DD, Crowe NA, Moore JN, Fischer KJ, McGraw RA. Equine tumor necrosis factor alpha: cloning and expression in Escherichia coli, generation of monoclonal antibodies, and development of a sensitive enzyme-linked immunosorbent assay. Hybridoma. 1992 Dec;11(6):715-27.
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