Anti-Tumor Necrosis Factor (TNF) [9B10] Antibody
![Anti-Tumor Necrosis Factor (TNF) [9B10] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/3886_2001202001282638850.jpg "Anti-Tumor Necrosis Factor (TNF) [9B10] Antibody, 100ug")
This mouse IgG2b monoclonal antibody was generated against a 17-kDa recombinant equine tumor necrosis factor alpha (rETNFa) protein produced by activated macrophages and recognizes equine TNFa.
Highlights:
- Reacts with equine TNFa
- Some cross-reactivity observed with rHTNFa. None with nETNFß, nMTNFa, rMTNFß and rPTNFa
- Useful tool for the development of therapeutic agents against diseases associated with production of equine TNFa, such as Gram-negative infections, neonatal sepsis and auto-immune disorders
Tumor necrosis factor is a cell signaling protein or cytokine that is involved in inflammation, and specifically one of the proteins in the acute phase reaction. TNF is produced mainly by macrophages but other white cells too. Some of its roles are to induce fever, apoptotic cell death, inhibit tumorigenesis and inflammation. Diseases associated with dysregulation of TNF production include inflammatory bowel disease (IBD), Psoriasis, Alzheimer's and cancer.
From the laboratory of Royal A. McGraw, University of Georgia.
Part of The Investigator's Annexe program.
This mouse IgG2b monoclonal antibody was generated against a 17-kDa recombinant equine tumor necrosis factor alpha (rETNFa) protein produced by activated macrophages and recognizes equine TNFa.
Highlights:
- Reacts with equine TNFa
- Some cross-reactivity observed with rHTNFa. None with nETNFß, nMTNFa, rMTNFß and rPTNFa
- Useful tool for the development of therapeutic agents against diseases associated with production of equine TNFa, such as Gram-negative infections, neonatal sepsis and auto-immune disorders
Tumor necrosis factor is a cell signaling protein or cytokine that is involved in inflammation, and specifically one of the proteins in the acute phase reaction. TNF is produced mainly by macrophages but other white cells too. Some of its roles are to induce fever, apoptotic cell death, inhibit tumorigenesis and inflammation. Diseases associated with dysregulation of TNF production include inflammatory bowel disease (IBD), Psoriasis, Alzheimer's and cancer.
From the laboratory of Royal A. McGraw, University of Georgia.
Part of The Investigator's Annexe program.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Antigen: | Tumor Necrosis Factor (TNF) |
| Accession ID: | P01375 |
| Molecular Weight: | 17 kDa |
| Isotype: | IgG2b |
| Clonality: | Monoclonal |
| Clone Name: | 9B10 |
| Reactivity: | Equine |
| Immunogen: | Recombinant equine tumor necrosis factor alpha |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Storage: | -20C |
| Shipped: | Cold packs |
- Su X, Morris DD, Crowe NA, Moore JN, Fischer KJ, McGraw RA. Equine tumor necrosis factor alpha: cloning and expression in Escherichia coli, generation of monoclonal antibodies, and development of a sensitive enzyme-linked immunosorbent assay. Hybridoma. 1992 Dec;11(6):715-27.
If you publish research with this product, please let us know so we can cite your paper.
