Anti-Filamin-A Antibody
This rabbit IgG polyclonal antibody was generated against human smooth muscle filamin purified from smooth muscle and is specific for human smooth muscle filamin, filamin A.
Highlights:
- Reacts with human filamin A
- Recommended for Western Blot applications
The smooth muscle filamin ( Filamin A) gene encodes an actin-binding protein that joins actin filaments and links actin filaments to membrane glycoproteins. Filamin A is involved in remodeling the cytoskeleton changing cell shape and aiding in migration. Filamin A interacts with integrins, transmembrane receptor complexes, and second messengers. Mutations in Filamin A result in periventricular nodular heterotopias (PVNH1, PVNH4), Melnick-Needles syndrome (MNS), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX).
From the laboratories of David W. Speicher, PhD, The Wistar Institute.
This rabbit IgG polyclonal antibody was generated against human smooth muscle filamin purified from smooth muscle and is specific for human smooth muscle filamin, filamin A.
Highlights:
- Reacts with human filamin A
- Recommended for Western Blot applications
The smooth muscle filamin ( Filamin A) gene encodes an actin-binding protein that joins actin filaments and links actin filaments to membrane glycoproteins. Filamin A is involved in remodeling the cytoskeleton changing cell shape and aiding in migration. Filamin A interacts with integrins, transmembrane receptor complexes, and second messengers. Mutations in Filamin A result in periventricular nodular heterotopias (PVNH1, PVNH4), Melnick-Needles syndrome (MNS), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX).
From the laboratories of David W. Speicher, PhD, The Wistar Institute.
| Product Type: | Antibody |
| Alternative Name(s): | Actin-binding protein 280, ABP-280, Alpha-filamin, Endothelial actin-binding protein, Filamin-1,Non-muscle filamin |
| Antigen: | Human Smooth Muscle Filamin, Filamin A |
| Accession ID: | P21333 |
| Isotype: | IgG |
| Clonality: | Polyclonal |
| Reactivity: | Human |
| Immunogen: | Human Smooth Muscle Filamin Purified from Smooth Muscle |
| Species Immunized: | Rabbit |
| Purification Method: | Affinity Purified using Human Smooth Muscle Filamin |
| Tested Applications: | Western Blot (1:2,000; 20sec exposure) |
| Storage: | -80C |
| Shipped: | Cold Packs (Domestic, Overnight); Dry Ice (International) |
Western Blot
Lane 1, Human Red Cell Membrane; Lane 2, Human Ovarian Cancer (OVCAR3); Lane 5, Human Ovarian Cancer (OV90). Gel loads: Lane 1, 5mg; Lanes 2, 25mg. Antibody dilution: 1:2,000, 20sec exposure.
- Hock RS, Davis G, Speicher DW. Purification of human smooth muscle filamin and characterization of structural domains and functional sites. Biochemistry. 1990 Oct 9;29(40):9441-51.
If you publish research with this product, please let us know so we can cite your paper.
