Methyltetrazine-activated TAMRA dye reacts with TCO-containing compounds via a Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures.
Tetrazine/TCOs are heterobifunctional reagents used for converting azido-containing peptides or protein into tetrazine-modified peptides or protein without the need for catalyst or axillary reagents. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is a bioorthogonal reaction that possesses exceptional kinetics (k > 800 -1s-1) and selectivity. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair described to date.
Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
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Product Type: | Small Molecule |
CAS number: | N/A |
Molecular Weight: | 776.83 |
Extinction Coefficient: | 92000 |
Variant MPN: | 1026 |
Format: | Red amorphous solid |
Purity: | >90% (HPLC) |
Solubility: | Water, DMSO, DMF, MeOH |
Spectral Information: | Abs/Em = 553/575 nm |
Storage: | -20C.Desiccate |
Shipped: | Ambient |
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