Anti-VSV-M [23H12] Antibody
This monoclonal antibody reacts with VSV-M protein.
Highlights:
- Reacts with VSV-M protein
- Suitable for Western Blot applications
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma 23H12
Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The G protein (glycoprotein) is located at the virion surface and is responsible for virus attachment and penetration. Additionally, many lentivrial vectors are pseudotyped with VSV-G from the Indiana serotype.
Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The M protein (or matrix protein) is responsible for binding the nucleocapsid and condenses it into a tightly coiled helix and binds the nucleocapsid to the envelope. This activity of the M protein is what gives the virus its bullet like shape. In addition to M protein's role in virus assembly, it is also responsible for mediating molecular mechanisms of VSV pathogenesis. Wild-type M protein surpresses host gene expression in infected cells and inhibits antiviral responses.
From the laboratory of Douglas S. Lyles, PhD, Wake Forest School of Medicine.
This monoclonal antibody reacts with VSV-M protein.
Highlights:
- Reacts with VSV-M protein
- Suitable for Western Blot applications
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma 23H12
Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The G protein (glycoprotein) is located at the virion surface and is responsible for virus attachment and penetration. Additionally, many lentivrial vectors are pseudotyped with VSV-G from the Indiana serotype.
Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The M protein (or matrix protein) is responsible for binding the nucleocapsid and condenses it into a tightly coiled helix and binds the nucleocapsid to the envelope. This activity of the M protein is what gives the virus its bullet like shape. In addition to M protein's role in virus assembly, it is also responsible for mediating molecular mechanisms of VSV pathogenesis. Wild-type M protein surpresses host gene expression in infected cells and inhibits antiviral responses.
From the laboratory of Douglas S. Lyles, PhD, Wake Forest School of Medicine.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
Specifications
| Product Type: | Antibody |
| Name: | Anti-VSV-M [23H12] |
| Antigen: | VSV-M |
| Accession ID: | P03519 |
| Host: | Mouse |
| Isotype: |
EB0011: IgG2a kappa Recombinant versions: see product name |
| Clonality: | Monoclonal |
| Clone Name: | 23H12 |
| Specificity: | VSV-Ind matrix (M) protein |
| Reactivity: | Human |
| Immunogen: | VSV infection |
| Format: | Liquid |
| Purification Method: | Protein G purified |
| Buffer: |
EB0011: PBS, 0.05% (w/v) Sodium Azide Recombinant versions: PBS with 0.02% Proclin 300 |
| Tested Applications: | Western blot (1:1000) |
| Concentration: | 1mg/mL |
| Amount: | 100uL |
| Storage: | -20C (avoid repeated freeze / thaw cycles) |
| Shipped: | Cold packs |
Provider
From the laboratory of Douglas S. Lyles, PhD, Wake Forest School of Medicine.
References
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