Anti-Dentin matrix protein-1 (DMP1), E261-E275 [LF-148] Antibody
![Anti-Dentin matrix protein-1 (DMP1), E261-E275 [LF-148] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1516_2001202001265015150.jpg "Anti-Dentin matrix protein-1 (DMP1), E261-E275 [LF-148] Antibody")
This rabbit IgG polyclonal antibody was generated against peptide and recognizes human or cow Dentin matrix protein-1 (DMP1).
Highlights:
- Recognizes human and cow DMP1- Epitope EHPSRKIFRKSRISE and LKNIEIESRKLTVDAYH
- Suitable for Immunohistochemistry and Western Blot applications
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia.
From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research/NIH.
This rabbit IgG polyclonal antibody was generated against peptide and recognizes human or cow Dentin matrix protein-1 (DMP1).
Highlights:
- Recognizes human and cow DMP1- Epitope EHPSRKIFRKSRISE and LKNIEIESRKLTVDAYH
- Suitable for Immunohistochemistry and Western Blot applications
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia.
From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research/NIH.
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| Product Type: | Antibody |
| Antigen: | Dentin matrix protein-1 (DMP1), human |
| Accession ID: | Q13316 |
| Molecular Weight: | 55782 Da |
| Clonality: | Polyclonal |
| Clone Name: | LF-148 |
| Reactivity: | Human, cow |
| Immunogen: | Peptide |
| Species Immunized: | Rabbit |
| Epitope: | EHPSRKIFRKSRISE and LKNIEIESRKLTVDAYH |
| Buffer: | Whole serum |
| Tested Applications: | WB 1:2000, IHC 1:200 |
| Storage: | -80C |
| Shipped: | Cold Packs (Domestic, Overnight); Dry Ice (International) |
- Ogbureke KU, Fisher LW. Expression of SIBLINGs and their partner MMPs in salivary glands. J Dent Res. 2004 Sep;83(9):664-70. PubMed PMID: 15329369.
- von Marschall Z, Fisher LW. Dentin matrix protein-1 isoforms promote differential cell attachment and migration. J Biol Chem. 2008 Nov 21;283(47):32730-40.
- Jain A, Karadag A, Fohr B, Fisher LW, Fedarko NS. Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attack. J Biol Chem. 2002 Apr 19;277(16):13700-8. Epub 2002 Feb 1. PubMed PMID: 11825898.
- Farrow EG, Davis SI, Ward LM, Summers LJ, Bubbear JS, Keen R, Stamp TC, Baker LR, Bonewald LF, White KE. Molecular analysis of DMP1 mutants causing autosomal recessive hypophosphatemic rickets. Bone. 2009 Feb;44(2):287-94.
- Maciejewska I, Cowan C, Svoboda K, Butler WT, D'Souza R, Qin C. The NH2-terminal and COOH-terminal fragments of dentin matrix protein 1 (DMP1) localize differently in the compartments of dentin and growth plate of bone. J Histochem Cytochem. 2009 Feb;57(2):155-66.
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