Anti-Osteopontin (SPP1), human Exon 4 [LF-161] Antibody
![Anti-Osteopontin (SPP1), human Exon 4 [LF-161] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1522_2001202001265115210.jpg "Anti-Osteopontin (SPP1), human Exon 4 [LF-161] Antibody")
This rabbit IgG polyclonal antibody was generated against peptide (exon 4) and is specific for human Osteopontin (SPP1).
Highlights:
- Recognizes human Osteopontin (SPP1) - Epitope LYNKYPDAVATWLNPDPSQKQNLLAPN
- Suitable for Immunohistochemistry and Western Blot applications
Osteopontin is a phosphoglycoprotein synthesized in a variety of tissues and cells. It was originally identified as a bone matrix protein and subsequently as a cytokine produced by various immune and transformed cell lines. OPN is a biomarker for various types of cancers and inflammatory diseases. Excessive or dysregulated OPN expression has been linked to the pathogenesis of both autoimmune disorders such as multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, atherosclerosis and other inflammatory diseases including cardiovascular disease, chronic obstructive pulmonary disease, inflammatory bowel disease, liver disease and asthma.
From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research/NIH.
This rabbit IgG polyclonal antibody was generated against peptide (exon 4) and is specific for human Osteopontin (SPP1).
Highlights:
- Recognizes human Osteopontin (SPP1) - Epitope LYNKYPDAVATWLNPDPSQKQNLLAPN
- Suitable for Immunohistochemistry and Western Blot applications
Osteopontin is a phosphoglycoprotein synthesized in a variety of tissues and cells. It was originally identified as a bone matrix protein and subsequently as a cytokine produced by various immune and transformed cell lines. OPN is a biomarker for various types of cancers and inflammatory diseases. Excessive or dysregulated OPN expression has been linked to the pathogenesis of both autoimmune disorders such as multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, atherosclerosis and other inflammatory diseases including cardiovascular disease, chronic obstructive pulmonary disease, inflammatory bowel disease, liver disease and asthma.
From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research/NIH.
This product is for sale to Nonprofit customers only. For profit customers, please Contact Us for more information.
| Product Type: | Antibody |
| Antigen: | Osteopontin (SPP1), human |
| Accession ID: | P10451 |
| Molecular Weight: | 35422 Da |
| Clonality: | Polyclonal |
| Clone Name: | LF-161 |
| Reactivity: | Human |
| Immunogen: | Peptide (exon 4) |
| Species Immunized: | Rabbit |
| Epitope: | LYNKYPDAVATWLNPDPSQKQNLLAPN |
| Buffer: | Whole serum |
| Tested Applications: | WB 1:2000, IHC 1:200 |
| Storage: | -80C |
| Shipped: | Cold Packs (Domestic, Overnight); Dry Ice (International) |
- Zduniak K, Ziolkowski P, Ahlin C, Agrawal A, Agrawal S, Blomqvist C, Fjällskog ML, Weber GF. Nuclear osteopontin-c is a prognostic breast cancer marker. Br J Cancer. 2015 Feb 17;112(4):729-38.
- Zduniak K, Agrawal A, Agrawal S, Hossain MM, Ziolkowski P, Weber GF. Osteopontin splice variants are differential predictors of breast cancer treatment responses. BMC Cancer. 2016 Jul 11;16:441.
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