Anti-Detyrosinated Alpha Tubulin [AA12] Antibody
This IgG2a mouse antibody was generated against alpha tubulin (GEEEGE) and recognizes all mammalian homologs as well as detyrosinated alpha tubulin, a post-translational modification of alpha tubulin.
Highlights:
- Reacts with alpha tubulin
- Suitable for Western Blot, Immunoprecipitation, Immunohistochemistry and Immunofluorescence applications
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma AA12
Microtubules are required for many well characterized functions in eukaryotic cells, including the movement of chromosomes in mitosis and meiosis, intracellular transport, establishment and maintenance of cellular morphology, cell growth, cell migration and morphogenesis in multicellular organisms. The building block of a microtubule is the tubulin subunit, a heterodimer of alpha and beta tubulin. Both of these monomers are found in all eukaryotes, and their sequences are highly conserved. The tubulin protein is a major target of drug molecules, and consequently, tubulin inhibitors have attracted great attention as antimitotic antitumor agents for chemotherapeutic use.
From the laboratories of Anthony Frankfurter, PhD and Anthony Spano, PhD, University of Virginia.
This IgG2a mouse antibody was generated against alpha tubulin (GEEEGE) and recognizes all mammalian homologs as well as detyrosinated alpha tubulin, a post-translational modification of alpha tubulin.
Highlights:
- Reacts with alpha tubulin
- Suitable for Western Blot, Immunoprecipitation, Immunohistochemistry and Immunofluorescence applications
Recombinant versions available from our sister company, Absolute Antibody:
- Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e., specificity) from the hybridoma AA12
Microtubules are required for many well characterized functions in eukaryotic cells, including the movement of chromosomes in mitosis and meiosis, intracellular transport, establishment and maintenance of cellular morphology, cell growth, cell migration and morphogenesis in multicellular organisms. The building block of a microtubule is the tubulin subunit, a heterodimer of alpha and beta tubulin. Both of these monomers are found in all eukaryotes, and their sequences are highly conserved. The tubulin protein is a major target of drug molecules, and consequently, tubulin inhibitors have attracted great attention as antimitotic antitumor agents for chemotherapeutic use.
From the laboratories of Anthony Frankfurter, PhD and Anthony Spano, PhD, University of Virginia.
| Catalog Number | Product | DataSheet | Size | AVAILABILITY | Price | Qty |
|---|
| Product Type: | Antibody |
| Name: | Anti-Detyrosinated Alpha Tubulin [AA12] |
| Host: | balb/c mouse |
| Isotype: |
EG0039: IgG2a Recombinant versions: see product name |
| Clonality: | Monoclonal |
| Clone Name: | AA12 |
| Specificity: | Alpha Tubulin (all mammalian homologs) |
| Immunogen: | Generated against alpha tubulin (GEEEGE) |
| Format: | Liquid |
| Purification Method: | Protein G affinity purified |
| Buffer: |
EG0039: PBS, 0.05% (w/v) Sodium Azide Recombinant versions: PBS with 0.02% Proclin 300 |
| Tested Applications: | WB (1:1000), IHC, IP, IF (1:500) |
| Concentration: | 1mg/mL |
| Amount: | 100uL |
| Storage: | -20C |
| Shipped: | Cold packs |
- Esteve MA, Carre M, Bourgarel-Rey V, Kruczynski A, Raspaglio G, Ferlini C, Braguer D. Bcl-2 down-regulation and tubulin subtyppe composition are involved in resistance of ovarian cancer cells to vinflunine. Mol Cancer Ther. 5(11):2824-2833, (2006).
If you publish research with this product, please let us know so we can cite your paper.
