Robert W. Sobol, PhD, University of South Alabama
Research in the Sobol lab focuses on the mechanism of base excision repair, PARP and NAD+ metabolism in human cells and the convergent role of these enzymes and pathways in response to environmental Genotoxins and chemotherapy. A major goal in the lab is to use biochemical, genetic and imaging modalities to study the protein complexes of the base excision repair pathway that respond to DNA damage induced by Genotoxins and chemotherapy and how this pathway affects the regulation of cellular metabolism via ADP-ribosylation signaling and alterations in NAD+ metabolism. Dr. Sobol's research has been funded by grants from the National Institutes of Health (NIH), American Cancer Society, the Susan G. Komen Breast Cancer Foundation and the Brain Tumor Society, among others.
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References
- Koczor CA, Saville KM, Andrews JF, Clark J, Fang Q, Li J, Al-Rahahleh RQ, Ibrahim M, McClellan S, Makarov MV, Migaud ME, Sobol RW. Temporal dynamics of base excision/single-strand break repair protein complex assembly/ disassembly are modulated by the PARP/NAD+/SIRT6 axis. Cell Rep. 2021 Nov 2;37(5):109917. doi: 10.1016/j.celrep.2021.109917. PMID: 34731617
