David Kaplan, PhD, Tufts University
Dr. Kaplan’s lab focuses on biomaterials derived from biopolymer engineering and on tissue engineering and regenerative medicine. The team utilizes fibrous proteins from nature (e.g., elastins, silks, collagens, resilins) and bioengineered variants to study structure-function from both fundamental and applied views. They have pioneered the study of silk protein-based biomaterials with the emergence of silk as a new option in the degradable polymer field with excellent biocompatibility, new fundamental understanding of control of water to regulate structure and properties, and new tissue-specific outcomes with silk as scaffolding in gel, fiber, film, sponge and dense medical device formats. Recent efforts focus on dynamic protein-based biomaterials utilizing silk-elastin copolymers and on modulating crystallization related to sustained drug delivery.
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References:
- Saad MK, Yuen JSK Jr, Joyce CM, et al. Continuous fish muscle cell line with capacity for myogenic and adipogenic-like phenotypes. Sci Rep. 2023;13(1):5098. Published 2023 Mar 29. doi:10.1038/s41598-023-31822-2
- Michael K Saad, John SK Yuen Jr, Connor M Joyce, Xinxin Li, Taehwan Lim, Talia L Wolfson, Justin Wu, Jason Laird, Sanjana Vissapragada, Olivia P Calkins, Adham Ali, David L Kaplan. Continuous Fish Muscle Cell Line with Capacity for Myogenic and Adipogenic-like Phenotypes. bioRxiv 2022.08.22.504874; doi: https://doi.org/10.1101/2022.08.22.504874
- Stout AJ, Arnett MJ, Chai K, et al. Immortalized Bovine Satellite Cells for Cultured Meat Applications. ACS Synth Biol. 2023;12(5):1567-1573. doi:10.1021/acssynbio.3c00216
