HDAC Inhibitors
Histone deacetylases (HDAC) comprise a family of enzymes that regulate chromatin remodeling, gene transcription, and activity of partner proteins. They control critical cellular processes, including cell growth, cell cycle regulation, DNA repair, differentiation, proliferation, and apoptosis. Chemical inhibitors of HDACs have been shown to inhibit tumor cell growth and induce differentiation and cell death.
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