John C. Herr, PhD, University of Virginia
John C. Herr, PhD
The Herr laboratory is focused on the structural characterization of sperm proteins and their encoding genes. The goals of their research are to identify sperm proteins which are testis-specific, to understand which are autoantigens, and to identify when these proteins arise during spermatogenesis and how they are arranged within the mature sperm cell. Particular attention is given to understanding the fate of these proteins during events in the life of a sperm, such as the acrosome reaction and sperm-egg interactions during fertilization.
Part of The Investigator's Annexe program.
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References
- Diekman AB, Norton EJ, Klotz KL, Westbrook VA, Shibahara H, Naaby-Hansen S, Flickinger CJ, and Herr JC. N-linked glycan of a sperm CD52 glycoform associated wiht human infertility. FASEB J. 13(11):1303-1313, (1999).
