Lester I. Binder, PhD, University of Virginia
Lester I. Binder, PhD
The Binder Lab is interested in understanding the mechanisms by which the Tau protein, which is thought to be vital to maintaining neurons in healthy cells, is transformed into a pathological entity. Tau protein can bind to and stabilize microtubules, thereby helping to maintain the neuronal cytoskeleton. However, in many disease states the tau molecule forms fibrils that accumulate in pathological structures, leading to neurodegeneration.
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References
- Binder LI, Frankfurter A, and Rebhun LI. The distribution of Tau in mammalian central nervous system. J Cell Biol. 101(4):1371-8 (1985).
