James H. Morrissey, PhD, University of Michigan

James H. Morrissey, PhD
James H. Morrissey, PhD

Research conducted in the Morrissey laboratory focuses on understanding how cells regulate blood clotting in health and disease. The blood clotting system is activated when an enzyme (a specific plasma serine protease known as factor VIIa) binds to a particular integral membrane protein (known as tissue factor, or TF) on cell surfaces. The TF-VIIa-membrane complex triggers the blood clotting cascade by activating two plasma serine protease zymogens (factor IX and factor X) via limited proteolysis.

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References

  1. Rao NN, Gómez-García MR, and Kornberg A. Inorganic polyphosphate: essential for growth and survival. Annu Rev Biochem. 78:605-647, 2009.
  2. Choi SC et al. Phosphoramidate end labeling of inorganic polyphosphates: facile manipulation of polyphosphate for investigating and modulating its biological activities. Biochemistry 49(45):9935-41, 2010.
  3. Morrissey JH, Choi SH, and Smith S.A. Polyphosphate: an ancient molecule that links platelets, coagulation and inflammation. Blood 119:5972-5979, 2012.
  4. Smith SA et al. Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation. Blood 120(26):5103-10, 2012.
  5. Gajsiewicz JM, Smith SA, Morrissey JH. Polyphosphate and RNA Differentially Modulate the Contact Pathway of Blood Clotting. J Biol Chem. 2016 Dec 22. pii: jbc.M116.754325. View Article
  6. Morrissey JH. Poly-P as Modulator of Hemostasis, Thrombosis, and Inflammation. Blood 2017 130:SCI-1.