The Hollenbach laboratory focuses on understanding how phosphorylation of the transcription factor Pax3 regulates its biological activity to control muscle and melanocyte development and how alteration of this activity contributes to the development of the childhood solid muscle tumor alveolar rhabdomyosarcoma (ARMS) and melanoma. The lab has identified the three sites of phosphorylation on Pax3, they have identified two of the three kinases responsible for phosphorylating these sites, and they have determined that the pattern of Pax3 phosphorylation changes significantly during the first eight hours of myogenesis.
Part of The Investigator's Annexe program.