David A. Fox, MD, University of Michigan

David A. Fox, MD
David A. Fox, MD

Research in Dr. Fox's laboratory is directed at defining and characterizing pathways of human T cell activation, and the role of these pathways in the pathogenesis of autoimmune diseases, especially rheumatoid arthritis. Two principal areas of study include: 1- interactions between synovial fibroblasts and T cells, and 2- regulation of Th17 cells. One approach used has been to generate monoclonal antibodies against T lymphocyte populations from autoimmune lesions, for example, from synovial tissue and synovial fluid derived from patients with rheumatoid arthritis. Antibodies are then screened for preferential reactivity with lesional T cells and for functional effects.

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References

  1. Higgs JB, Zeldes W, Kozarsky K, Schteingart M, Kan L, Bohlke P, Krieger K, Davis W, Fox DA. A novel pathway of human T lymphocyte activation. Identification by a monoclonal antibody generated against a rheumatoid synovial T cell line. J Immunol. 1988 Jun 1;140(11):3758-65.
  2. Fox DA, Millard JA, Kan L, Zeldes WS, Davis W, Higgs J, Emmrich F, Kinne RW. Activation pathways of synovial T lymphocytes. Expression and function of the UM4D4/CDw60 antigen. J Clin Invest. 1990 Oct;86(4):1124-36.
  3. Fox DA, He X, Abe A, Hollander T, Li LL, Kan L, Friedman AW, Shimizu Y, Shayman JA, Kozarsky K. The T lymphocyte structure CD60 contains a sialylated carbohydrate epitope that is expressed on both gangliosides and glycoproteins. Immunol Invest. 2001 May;30(2):67-85.
  4. Ginsburg D, Bockenstedt PL, Allen EA, Fox DA, Foster PA, Ruggeri ZM, Zimmerman TS, Montgomery RR, Bahou WF, Johnson TA, et al. Fine mapping of monoclonal antibody epitopes on human von Willebrand factor using a recombinant peptide library. Thromb Haemost. 1992 Jan 23;67(1):166-71.