David Thorley-Lawson, PhD, Tufts University
David Thorley-Lawson, PhD
The Thorley-Lawson Lab studied the mechanism of persistence of the oncogenic human herpes virus Epstein-Barr virus. They found that the virus infects B lymphocytes and drives them to proliferate and differentiate so that it can establish persistent infection in memory B cells. When this process is disrupted the proliferative intermediates can give rise to tumors. They also analyzed the signaling pathways that regulate benign persistence and what changes to produce EBV associated tumors.
Part of The Investigator's Annexe program.
Products
References
- Mann KP, Staunton D, Thorley-Lawson DA. Epstein-Barr virus-encoded protein found in plasma membranes of transformed cells. J Virol. 1985 Sep;55(3):710-20.
