The Dratz lab uses global proteomic analysis to investigate signaling networks in cells and studies the structure and function of membrane receptor and amplifier proteins.
Epstein MG, Reeves BD, Maaty WS, Fouchard D, Dratz EA, Bothner B, Grieco PA. Enhanced sensitivity employing zwitterionic and pI balancing dyes (Z-CyDyes) optimized for 2D-gel electrophoresis based on side chain modifications of CyDye fluorophores. New tools for use in proteomics and diagnostics. Bioconjug Chem. 2013 Sep 18;24(9):1552-61.
Reeves BD, Joshi N, Campanello GC, Hilmer JK, Chetia L, Vance JA, Reinschmidt JN, Miller CG, Giedroc DP, Dratz EA, Singel DJ, Grieco PA. Conversion of S-phenylsulfonylcysteine residues to mixed disulfides at pH 4.0: utility in protein thiol blocking and in protein-S-nitrosothiol detection. Org Biomol Chem. 2014 Jul 2.
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