Kevin P. Campbell, PhD, University of Iowa
Kevin P. Campbell, PhD
Dr. Campbell's lab is interested in elucidating mechanisms underlying muscular dystrophy. His laboratory is currently focused on why O-glycosylation of dystroglycan is essential for this protein's function as an extracellular matrix receptor and how abnormalities in the O-glycosylation of dystroglycan cause muscular dystrophy. The goal of this research is to generate new knowledge regarding the function of dystroglycan, to identify and define disease mechanisms that cause muscular dystrophy, and to develop therapeutic strategies for these diseases.
Part of The Investigator's Annexe program.
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References
- Ervasti JM, Ohlendieck K, Kahl SD, Gaver MG, and Campbell KP. Deficiency of a Glycoprotein Component of the Dystrophin Complex in Dystrophic Muscle. Nature 345, 315-319, 1990
- Ohlendieck K and Campbell KP Dystrophin-Associated Proteins are Greatly Reduced in Skeletal Muscle from mdx Mice. J. Cell Biol. 115, 1685-1694, 1991
- Ohlendieck K, Ervasti JM, Snook JB, and Campbell KP. Dystrophin-glycoprotein complex is highly enriched in isolated skeletal muscle sarcolemma . J. Cell Biol. 112 :135-148, 1991.
- Durbeej, M, Larsson, E, Ibraghimov-Beskrovnaya O, Roberds SL, Campbell KP, and Ekblom P. Non-Muscle alpha-Dystroglycan Is Involved In Epithelial Development. J. Cell Biol. 130, 79-91, 1995.
