Ming-Sound Tsao, MD, FRCPC, University Health Network, Canada
The Tsao Laboratory is focused on translational research projects in lung and pancreatic cancer. The primary goals of their lung cancer projects are to identify novel genes or proteins that are better than clinical predictors alone in predicting clinical outcome or response to therapies. They profile the gene expression and genomic aberrations of a large number of human lung cancer samples using microarray techniques, apply computational bioinformatic algorithms to identify the predictive genes or gene signatures, and validate them by realtime quantitative PCR techniques. The biological functions of the predictive genes are then studied using in vitro lung cancer cell line models, primary lung cancer xenograft models and orthotopic rodent models of human lung cancers.
Part of The Investigator's Annexe program.
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References
- Radulovich N, Qian JY, Tsao MS. Human pancreatic duct epithelial cell model for KRAS transformation. Methods Enzymol. 2008;439:1-13.
