Walter J. Chazin, PhD, Vanderbilt University
Walter J. Chazin, PhD
Research in the Chazin laboratory seeks to characterize the structure and motions of proteins and nucleic acids, and the way in which they interact with other proteins, nucleic acids and drugs. We are in essence using the power of the chemistry approach to address key problems in biology and medicine. NMR spectroscopy is the primary experimental tool, though in studying these complex biomolecules, we make use of other biophysical and structural techniques, including X-ray crystallography, calorimetry, fluorescence spectroscopy and X-ray scattering.
Part of The Investigator's Annexe program.
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References
- Kehl-Fie TE, Chitayat S, Hood MI, Damo S, Restrepo N, Garcia C, Munro KA, Chazin WJ, Skaar EP. Nutritional metal sequestration by calprotectin enhances neutrophil killing of Staphylococcus aureus through inhibition of superoxide defense. Cell Host and Microbe 10, 158-164 (2011).
- Damo SM, Kehl-Fie TE, Sugitani N, Holt ME, Rathi S, Murphy WJ, Zhang Y, Betz C, Hench L, Fritz G, Skaar EP, Chazin WJ. Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens". Proc. Natl. Acad. Sci., USA 110, 3841-3846 (2013).
