Oliver Kerscher, PhD, College of William & Mary

Oliver Kerscher, PhD
Oliver Kerscher, PhD

Ubiquitin and SUMO, two small proteins modifiers, control important aspects of the cell division program in eukaryotic cells. The Kerscher Lab studies the consequences of SUMO-modification on protein targeting and function during cell division. They are particularly interested in the SUMO protease Ulp1 and SUMO-targeted Ubiquitin ligases (STUbLs). The ultimate goal of their research is to elucidate how SUMO-modification safeguards the transmission and maintenance of genetic information.

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References

  1. Elmore ZC, Donaher M, Matson BC, Murphy H, Westerbeck JW, Kerscher O. Sumo-dependent substrate targeting of the SUMO protease Ulp1. BMC Biol. 2011 Oct 28;9:74. doi: 10.1186/1741-7007-9-74.
  2. Peek J, Harvey C, Gray D, Rosenberg D, Kolla L, Levy-Myers R, Yin R, McMurry JL, Kerscher O. SUMO targeting of a stress-tolerant Ulp1 SUMO protease. PLoS One. 2018 Jan 19;13(1):e0191391. doi: 10.1371/journal.pone.0191391.