Kefei Yu, PhD, Michigan State University

Kefei Yu, PhD
Kefei Yu, PhD

The Yu lab studies DNA recombination and DNA repair in immune cells in association with antigen receptor gene diversification. This includes the site-directed V(D)J recombination that assembles the antigen binding domain of the immunoglobulin (Ig) and T cell receptor genes; and a region-specific class switch recombination (CSR) that changes the Ig constant region. Both events involve DNA double strand break intermediates that, if not repaired properly, can cause chromosomal deletions or translocations.

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References

  1. Masani S, Han L, Meek K, Yu K. Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination. Proc Natl Acad Sci U S A. 2016, 113(5):1261-6.
  2. Han L, Masani S, Hsieh CL, Yu K. DNA ligase I is not essential for mammalian cell viability. Cell Rep. 2014 Apr 24;7(2):316-20.
  3. Masani S, Han L, Yu K. Apurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination. Mol Cell Biol. 2013 Apr;33(7):1468-73. doi: 10.1128/MCB.00026-13.
  4. Han L, Masani S, Yu K. Cutting edge: CTNNBL1 is dispensable for Ig classswitch recombination. J Immunol. 2010 Aug 1;185(3):1379-81.
  5. Han L, Yu K. Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV-deficient B cells. J Exp Med. 2008 Nov 24;205(12):2745-53.