Dr. Kanthasamy's research focuses on the cellular and molecular mechanisms of Parkinson's disease and other protein misfolding neurodegenerative disorders including prion diseases and Chronic Traumatic Encephalopathy, which is similar to Alzheimer's disease. His research program studies the role of environmental neurotoxic chemicals and other neurotoxic stress on pathogenesis of Parkinson's and other neurodegenerative diseases. He has also made several fundamental advances in signal transduction mechanisms associated with neuronal cell death processes.