The Chan laboratory studies autoantigens and autoantibodies associated with systemic autoimmune diseases and cancer. Their two main directions are: 1) To identify and characterize specific target antigens of human autoantibodies with a focus on understanding why autoantibodies are induced and continually produced in different disease, and 2) To use human autoantibodies as unique probes to investigate the molecular and cell biology of interesting macromolecules and subcellular organelles which have become autoimmune targets. The overall strategy is that by understanding the biology of autoantigens in health and disease states, they may be able to fully appreciate the functional and pathogenic potentials of autoantibodies. Chan Lab Webpage