Peter Sutovsky, PhD, University of Missouri - Columbia

Peter Sutovsky
Peter Sutovsky, PhD

Dr. Sutovsky's research has implicated the ubiquitin-proteasome pathway in the control of mitochondrial inheritance after mammalian fertilization and in the proteolytic mechanism for the sperm quality control during spermatogenesis. The central hypothesis of this research is that the maturation and function of human and animal spermatozoa is guided by the ubiquitin system in the testis, epididymis, and during/after fertilization. The components of the ubiquitin system in the spermatozoon are compartmentalized and developmentally regulated. The respective ubiquitin-dependent machineries regulate spatially and temporally separated events during the sperm cell life, such as sperm production in the testis, sperm maturation in the epididymis, penetration of the egg coat, zona pellucida during fertilization, targeted degradation of the paternal mitochondria, harboring paternal mitochondrial genes inside the fertilized egg.

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References

  1. Ahlering P, Sutovsky P, (2014) Biomarker-based flow-cytometric semen analysis for male infertility diagnostics and clinical decision making in ART. In: Screening for the Single Euploid Embryo - Molecular Genetics in Reproductive Medicine, Eric Scott Sills, Editor, Springer Science+Media LLC, p. 33-51.
  2. Buckman CL, Ozanon C, Qiu J, Sutovsky M, Carafa JA, Rawe VY, Manandhar G, Miranda-Vizuete A, Sutovsky P (2013) Semen levels of spermatid-specific thioredoxin-3 correlate with pregnancy rates in ART couples. PLoS ONE, e61000. doi: 10.1371.
  3. Jiménez A, Zu W, Rawe VY, Pelto-Huikko M, Flickinger CJ, Sutovsky P, Gustafsson J-A, Oko R and Antonio Miranda-Vizuete A. (2004) Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi apparatus-associated thioredoxin, is a specific marker of aberrant spermatogenesis. J. Biol. Chem. 279(33):34971-34982.
  4. 4. Miranda-Vizuete A, Sadek CM, Jiménez A, Krause WJ, Sutovsky P and Oko R (2004) The mammalian testis-specific thioredoxin system. Antioxid Redox Signal. 6:25-40.