Elizabeth M. Wilson, PhD, University of North Carolina at Chapel Hill

Elzabeth M. Wilson, MD
Elizabeth M. Wilson, PhD

The Wilson laboratory studies steroid hormone receptors are ligand-activated transcription factors that regulate gene expression by binding specific DNA sequences and interacting with other transcriptional regulatory proteins. They study the androgen receptor, the steroid receptor that mediates the biological effects of testosterone and dihydrotestosterone. Their focus is understanding molecular mechanisms of androgen receptor action. They use a variety of techniques to establish structure-function relationships in the ligand binding, DNA binding and transcriptional activation domains of the receptor. Specific naturally occurring mutations in the androgen receptor gene cause the androgen insensitivity syndrome that help in studies on receptor domain activity. Coactivator and corepressor proteins are being identified and characterized which interact with the receptor to modulate gene expression. They are determining mechanisms for androgen receptor reactivation in castration-recurrent prostate cancer.

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References

  1. Askew EB, Bai S, Hnat AT, Minges JT, Wilson EM 2009 Melanoma antigen gene protein-A11 (MAGE-11) F-box links the androgen receptor NH2-terminal transactivation domain to p160 coactivators. J Biol Chem 284:34793-34808.
  2. Askew EB, Bai S, Blackwelder AJ, Wilson EM 2010 Transcriptional synergy between melanoma antigen gene protein-A11 (MAGE-11) and p300 in androgen receptor signaling. J Biol Chem 285:21824-21836.
  3. Su S, Blackwelder AJ, Grossman G, Minges JT, Yuan L, Young SL, Wilson EM 2012 Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation. J Biol Chem 287:34809-34824.
  4. Minges JT, Su S, Grossman G, Blackwelder AJ, Pop EA, Mohler JL, Wilson EM 2013 Melanoma antigen-A11 (MAGE-A11) enhances transcriptional activity by linking androgen receptor dimers. J Biol Chem 288:1939-1952.
  5. Su S, Minges JT, Grossman G, Blackwelder AJ, Mohler JL, Wilson EM 2013 Proto-oncogene activity of melanoma antigen-A11 (MAGE-A11) regulates retinoblastoma-related p107 and E2F1 proteins. J Biol Chem 288:24809-24824.
  6. Minges JT, Grossman G, Zhang P, Kafri T, Wilson EM 2015 Post-translational down-regulation of melanoma antigen-A11 (MAGE-A11) by human p14-ARF tumor suppressor. J Biol Chem 290:25174-25187.
  7. Tan JA, Sharief Y, Hamil KG, Gregory CW, Zang DY, Sar M, Gumerlock PH, deVere White RW, Pretlow TG, Harris SE, Wilson EM, Mohler JL, French FS 1997 Dehydroepiandrosterone activates mutant androgen receptors expressed in the androgen dependent human prostate cancer xenograft CWR22 and LNCaP cells. Mol Endocrinol 11:450-459.
  8. Gregory CW, Johnson RT, Mohler JL, French FS, Wilson EM 2001 Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen. Cancer Res 61:2892-2898.
  9. Gregory CW, Whang YE, McCall W, Fei X, Liu Y, Ponguta LA, French FS, Wilson EM, Earp HS 2005 Heregulin-induced activation of HER2 and HER3 increases androgen receptor transactivation and CWR-R1 human recurrent prostate cancer cell growth. Clin Cancer Res 11:1704-1712.
  10. Shourideh M, DePriest A, Mohler JL, Wilson EM, Koochekpour S 2016 Characterization of fibroblast-free CWR-R1ca castration-recurrent prostate cancer cell line. Prostate 76:1067-1077.