Kazuko Nishikura, PhD, The Wistar Institute

Kazuko Nishikura, PhD
Kazuko Nishikura, PhD

The Nishikura laboratory studies the process of RNA editing and has made pioneering strides in the understanding of how our cells utilize RNA to control gene expression and protein synthesis and how the malfunction of this process can lead to disease. She discovered and characterized a family of enzymes called ADAR, which are responsible for editing the RNA transcribed from DNA.

Products

References

  1. Ota H, Sakurai M, Gupta R, Valente L, Wulff BE, Ariyoshi K, Iizasa H, Davuluri RV, Nishikura K. ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing. Cell. 2013 Apr 25;153(3):575-89. doi: 10.1016/j.cell.2013.03.024. PubMed PMID: 23622242; PubMed Central PMCID: PMC3651894.
  2. Chen CX, Cho DS, Wang Q, Lai F, Carter KC, Nishikura K. A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. RNA. 2000 May;6(5):755-67. PubMed PMID: 10836796; PubMed Central PMCID: PMC1369955.
  3. Cho DS, Yang W, Lee JT, Shiekhattar R, Murray JM, Nishikura K. Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA. J Biol Chem. 2003 May 9;278(19):17093-102. Epub 2003 Mar 4. PubMed PMID: 12618436.
  4. Wang Q, Khillan J, Gadue P, Nishikura K. Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis. Science. 2000 Dec 1;290(5497):1765-8. PubMed PMID: 11099415.