Maolin Guo, PhD, University of Massachusetts Dartmouth
Research in the Guo lab is in the interface between chemistry, biology and medicine. This exciting field is the foundation of modern biomedical sciences which provide molecular basis for various biomedical processes. They are using multi-disciplinary approach including molecular biology, protein chemistry, synthetic and electro-chemistry, spectroscopy (NMR, UV-vis, CD, fluorescent, etc), chromatography and X-ray crystallography to investigate the molecular basis of certain genes, proteins, metal ions and signal transduction pathways related to cancer, aging, infectious, cardiovascular diseases and neurodegenerative disorders. Their research goal is to understand the molecular basis of these biochemical processes and to develop novel strategies for diagnostics and therapeutics.
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References
- Wei Y, Aydin Z, Zhang Y, Liu Z, Guo M. A turn-on fluorescent sensor for imaging labile Fe(3+) in live neuronal cells at subcellular resolution. Chembiochem. 2012 Jul 23;13(11):1569-73. doi: 10.1002/cbic.201200202. Epub 2012 Jun 26. PubMed PMID: 22736480.
- Gupta A , Garreffi BP , Guo M . Facile synthesis of a novel genetically encodable fluorescent Α-amino acid emitting greenish blue light. Chem Commun (Camb). 2020 Oct 25;56(83):12578-12581. doi: 10.1039/d0cc03643a. Epub 2020 Sep 18. PMID: 32944728; PMCID: PMC7577945.
