Carrie L. Partch, PhD, University of California, Santa Cruz
Carrie L. Partch, PhD,
The Partch laboratory research is focused on identifying the fundamental basis of crosstalk between the circadian clock and DNA damage checkpoint response to understand how disruption of the clock regulates oncogenesis. They will achieve this by integrating diverse experimental approaches from cell biology to solution NMR spectroscopy to gain an atomic-level understanding of the clock, as well as providing new targets and/or a temporal basis for improved therapeutic intervention in cancer.
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References
- Gustafson CL, Parsley NC, Asimgil H, Lee HW, Ahlbach C, Michael AK, Xu H, Williams OL, Davis TL, Liu AC, Partch CL. A Slow Conformational Switch in the BMAL1 Transactivation Domain Modulates Circadian Rhythms. Mol Cell. 2017 May 18;66(4):447-457.e7.
- Xu H, Gustafson CL, Sammons PJ, Khan SK, Parsley NC, Ramanathan C, Lee HW, Liu AC, Partch CL. Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus. Nat Struct Mol Biol. 2015 Jun;22(6):476-484.
