Ravindra Uppaluri, MD, PhD, Dana-Farber Cancer Institute

Ravindra Uppaluri, MD, PhD
Ravindra Uppaluri, MD, PhD

Research in the Uppaluri laboratory focuses on the development and study of high-fidelity models of oral squamous cell carcinoma and translational applications of findings therein. A major effort in the laboratory has focused on molecular determinants of aggressiveness in oral squamous cell carcinomas (OSCC) that has lead to identification of (1) novel molecular signature that allow patient outcomes stratification (2) previously unexplored pathways in tumor cell aggressive growth and metastasis and (3) direct translational efforts in patients with oral cancer.

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References

  1. Onken MD, Winkler AE, Kanchi KL, Chalivendra V, Law JH, Rickert CG, Kallogjeri D, Judd NP, Dunn GP, Piccirillo JF, Lewis JS Jr, Mardis ER, Uppaluri R. A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease. Clin Cancer Res. 2014 Jun 1;20(11):2873-84. doi: 10.1158/1078-0432.CCR-14-0205. Epub 2014 Mar 25. PubMed PMID: 24668645; PubMed Central PMCID: PMC4096804.
  2. Judd NP, Allen CT, Winkler AE, Uppaluri R. Comparative analysis of tumor-infiltrating lymphocytes in a syngeneic mouse model of oral cancer. Otolaryngol Head Neck Surg. 2012 Sep;147(3):493-500. doi: 10.1177/0194599812442037. Epub 2012 Mar 19. PubMed PMID: 22434099; PubMed Central PMCID: PMC6346425.
  3. Judd NP, Winkler AE, Murillo-Sauca O, Brotman JJ, Law JH, Lewis JS Jr, Dunn GP, Bui JD, Sunwoo JB, Uppaluri R. ERK1/2 regulation of CD44 modulates oral cancer aggressiveness. Cancer Res. 2012 Jan 1;72(1):365-74. doi: 10.1158/0008-5472.CAN-11-1831. Epub 2011 Nov 15. PubMed PMID: 22086849; PubMed Central PMCID: PMC3286642.
  4. Kono M, Saito S, Egloff AM, Allen CT, Uppaluri R. The mouse oral carcinoma (MOC) model: A 10-year retrospective on model development and head and neck cancer investigations. Oral Oncol. 2022 Jul 9;132:106012. doi: 10.1016/j.oraloncology.2022.106012. Epub ahead of print. PMID: 35820346.