The Abraham laboratory seeks to understand at the molecular level how the human body tackles infections by agents that cause highly lethal human diseases that have limited treatment or vaccine options.
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References
Aricescu, A. R., Lu, W. & Jones, E. Y. A time- and cost-efficient system for high-level protein production in mammalian cells. Acta crystallographica. Section D, Biological crystallography 62, 1243–1250 (2006).
Abraham, J., Corbett, K. D., Farzan, M., Choe, H. & Harrison, S. C. Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses. Nature Structural & Molecular Biology 17, 438–444 (2010).
Lawrence CM, Ray S, Babyonyshev M, Galluser R, Borhani DW, Harrison SC. Crystal structure of the ectodomain of human transferrin receptor. Science. 1999 Oct 22;286(5440):779-82.
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