R. Elwyn Isaac, PhD, University of Leeds

The research in the Isaac laboratory exploits the amenable genetics and the sequenced genomes of the nematode, Caenorhabditis. elegans, and the fly, Drosophila melanogaster, to understand biochemical mechanisms of behaviour, development and reproduction. They are particularly interested in the role of neuropeptides and peptidases in controlling the behaviour and sex-life of insects and in understanding the various physiological roles of members of metallopeptidase gene families in invertebrates. They are also interested in the development of novel 'green' strategies to control insect pests by identifying target proteins for inhibitors and vaccines.

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References

  1. Siviter RJ, Taylor CA, Cottam DM, et al. Ance, a Drosophila angiotensin-converting enzyme homologue, is expressed in imaginal cells during metamorphosis and is regulated by the steroid, 20-hydroxyecdysone. Biochem J. 2002;367(Pt 1):187-193.
  2. Rylett CM, Walker MJ, Howell GJ, Shirras AD, Isaac RE. Male accessory glands of Drosophila melanogaster make a secreted angiotensin I-converting enzyme (ANCE), suggesting a role for the peptide-processing enzyme in seminal fluid. J Exp Biol. 2007;210(Pt 20):3601-3606.