Giuseppe A. Sautto, PhD, University of Georgia

Giuseppe A. Sautto, PhD
Giuseppe A. Sautto, PhD

Research in the Sautto lab is focused on the selection, cloning, characterization and engineering of monoclonal antibodies (mAbs), especially of human origin, and directed against infectious agents. In particular, the potential of these mAbs is investigated as possible drugs, able to directly neutralize infectious pathogens, or as indirect molecules to be exploited for the development of prophylactic approaches. Moreover, their possible engineering in order to improve (i.e. their binding or stability characteristics) or gain new functions (such as in the case of chimeric antigen receptors, CARs), represents a promising and alternative approach for difficult-to-eradicate infectious pathogens.

 

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References

  1. Sautto GA, Kirchenbaum GA, Abreu RB, Ecker JW, Pierce SR, Kleanthous H, Ross TM. A Computationally Optimized Broadly Reactive Antigen Subtype-Specific Influenza Vaccine Strategy Elicits Unique Potent Broadly Neutralizing Antibodies against Hemagglutinin. J Immunol. 2020 Jan 15;204(2):375-385. doi: 10.4049/jimmunol.1900379. Epub 2019 Dec 6. PMID: 31811019.
  2. Köppert S, Wolf C, Becza N, Sautto GA, Franke F, Kuerten S, Ross TM, Lehmann PV, Kirchenbaum GA. Affinity Tag Coating Enables Reliable Detection of Antigen-Specific B Cells in Immunospot Assays. Cells. 2021; 10(8):1843. https://doi.org/10.3390/cells10081843