Anti-Beta-Spectrin Antibody
This rabbit IgG polyclonal antibody was generated against purified human red blood cell spectrin beta-chain monomer and is specific for human red blood cell beta-spectrin.
Highlights:
- Reacts with human red blood cell beta-spectrin
- Recommended for Western Blot applications
Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane in eukaryotic cells along with actin. Spectrin plays a role in cell shape control, arrangement of transmembrane proteins, and organelle positioning. Beta-Spectrin functions as a structural element and stabilizes erythrocyte membranes. Mutations in beta-spectrin are described as a possible cause of neonatal hemolytic anemia, spherocytosis type 2, and hereditary elliptocytosis.
From the laboratories of David W. Speicher, PhD, The Wistar Institute.
This rabbit IgG polyclonal antibody was generated against purified human red blood cell spectrin beta-chain monomer and is specific for human red blood cell beta-spectrin.
Highlights:
- Reacts with human red blood cell beta-spectrin
- Recommended for Western Blot applications
Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane in eukaryotic cells along with actin. Spectrin plays a role in cell shape control, arrangement of transmembrane proteins, and organelle positioning. Beta-Spectrin functions as a structural element and stabilizes erythrocyte membranes. Mutations in beta-spectrin are described as a possible cause of neonatal hemolytic anemia, spherocytosis type 2, and hereditary elliptocytosis.
From the laboratories of David W. Speicher, PhD, The Wistar Institute.
| Product Type: | Antibody |
| Alternative Name(s): | Beta-I spectrin, Spectrin beta chain, erythrocytic |
| Antigen: | Human Red Blood Cell beta-Spectrin |
| Accession ID: | P11277 |
| Molecular Weight: | 246 kDa |
| Isotype: | IgG |
| Clonality: | Polyclonal |
| Reactivity: | Human |
| Immunogen: | Purified human red blood cell spectrin beta-chain monomer |
| Species Immunized: | Rabbit |
| Purification Method: | Rabbit serum |
| Tested Applications: | Western Blot (1:500,000; 10sec exposure) |
| Storage: | -80C |
| Shipped: | Cold Packs (Domestic, Overnight); Dry Ice (International) |
Western Blot
Lane 1, Human Melanoma (1205 LU); Lane 2, Human Ovarian Cancer (RMG1); Lane 3, Human Ovarian Cancer (OV90); Lane 4, Human Red Cell Membrane. Gel loads: Lanes 1-3, 25mg; Lane 4, 0.5mg. Antibody dilution: 1:500,000, 10sec exposure.
- Shih IM, Speicher D, Hsu MY, Levine E, Herlyn M. Melanoma cell-cell interactions are mediated through heterophilic Mel-CAM/ligand adhesion. Cancer Res. 1997 Sep 1;57(17):3835-40.
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