Recombinant HuD/ELAVL4 E Neoantigen
Recombinant HuD E/ELAVL4 neoantigen expressed in E. coli and purified via affinity chromatography.
Highlights:
- HuD E is a mutant derivative of HuD which is expressed in melanoma and SCLC tumor cells
- Can be used to detect the presence of tumor antibodies which may be uesfull in the detection of a tumor or its response to immunotherapy
ELAV-like protein 4 (ELAVL4, HuD) plays a role in neuron-specific RNA processing and protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). HuD binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA. HuD was originaly discovered as the paraneoplastic antigen expressed in neuroendocrine tumors. Recombinant HuD was first used to assay the presence of anti-Hu antibodies and thereby diagnose the presence of small cell lung cancer and subacute sensory neuronopathy. In normal cells , it functions to regulate gene expression and the recombinant protein has been used to identify regualtory elements in mRNA.
Recombinant HuD E/ELAVL4 neoantigen expressed in E. coli and purified via affinity chromatography.
Highlights:
- HuD E is a mutant derivative of HuD which is expressed in melanoma and SCLC tumor cells
- Can be used to detect the presence of tumor antibodies which may be uesfull in the detection of a tumor or its response to immunotherapy
ELAV-like protein 4 (ELAVL4, HuD) plays a role in neuron-specific RNA processing and protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). HuD binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA. HuD was originaly discovered as the paraneoplastic antigen expressed in neuroendocrine tumors. Recombinant HuD was first used to assay the presence of anti-Hu antibodies and thereby diagnose the presence of small cell lung cancer and subacute sensory neuronopathy. In normal cells , it functions to regulate gene expression and the recombinant protein has been used to identify regualtory elements in mRNA.
| Product Type: | Protein |
| Name: | Recombinant HuD E Protein |
| Accession ID: | P26378 |
| Source: | Recombinant from E. coli |
| Format: | Liquid |
| Buffer: | PBS, pH 7.2 |
| Tested Applications: | Detection of anti-Tumor antibodies via WB or ELISA assay |
| Storage: | -20C |
| Shipped: | Ambient temp. Upon delivery, aliquot and store at 4C (short term) or -20C (long term). |
SDS-PAGE Analysis
SDS Gel analysis of recombinant HuD E.
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