Hybrid PEI25/HA15-30-CAN-Fe2O3 Nanoparticles
Hybrid 25kDa branched polyethyleneimine PEI25/Hyaluronic acid (15-30 kDa)-CAN-maghemite nanoparticles.
Highlights:
- Functionalization: C3/4+ cation coordinative chemistries and polycationic polyNH2 / polyCOOH and /polyOH functional shells (reduced toxicity by charge reduction)
- Posess novel orthogonal surface chemistry/engineering for drugs, polymers, ect.
- Excellent for gene silencing applications (together with MRI tracking features)
- Compatible with different modes (e.g., coordinative and covalent) of PEI toxicity reduction/NP surface engineering
From the laboratory of Jean-Paul Lellouche, PhD, Bar-Ilan University.
Hybrid 25kDa branched polyethyleneimine PEI25/Hyaluronic acid (15-30 kDa)-CAN-maghemite nanoparticles.
Highlights:
- Functionalization: C3/4+ cation coordinative chemistries and polycationic polyNH2 / polyCOOH and /polyOH functional shells (reduced toxicity by charge reduction)
- Posess novel orthogonal surface chemistry/engineering for drugs, polymers, ect.
- Excellent for gene silencing applications (together with MRI tracking features)
- Compatible with different modes (e.g., coordinative and covalent) of PEI toxicity reduction/NP surface engineering
From the laboratory of Jean-Paul Lellouche, PhD, Bar-Ilan University.
Specifications
| Product Type: | Small Molecule |
| Core: | HA/b-PEI25-CAN–γ-Fe2O3 |
| Functionalization: | Hyaluronic acid 15-30KDa/ b-25 KDa-PEI functionalized CAN–γ-Fe2O3 NPs |
| Internal Contents: | γ-Fe2O3 maghemite phase with Ce3/4+ cation doping |
| Format: | spherical |
| Buffer: | ddH2O |
| Stability: | 4-6 months at +4C |
| Concentration: | 2.075 mg/mL |
| Size Distribution: | 0.4 PDI |
| Mean Diameter: | 96.3 ± 1.1 nm |
| Modification(s): | hyaluronic acid 15-30 KDa, Ha/Fe w/w ratio 10 |
| TEM: | 7.37 ± 1.35 nm |
| DLS: | 96.3 ± 1.1 nm |
| Zeta Potential: | +38.6 mV |
| TGA (weight loss): | 76.9%, 240-410C |
| Comments: | Refractive Index = 2.69 |
| Storage: | 4C |
| Shipped: | Cold packs |
Provider
From the laboratory of Jean-Paul Lellouche, PhD, Bar-Ilan University.
References
- Ishay, Rivka Ben, et al. "Maghemite-human serum albumin hybrid nanoparticles: towards a theranostic system with high MRI r 2* relaxivity." Journal of Materials Chemistry B 4.21 (2016): 3801-3814.
- Rosenberger I, Strauss A, Dobiasch S, Weis C, Szanyi S, Gil-Iceta L, Alonso E, González Esparza M, Gómez-Vallejo V, Szczupak B, Plaza-García S, Mirzaei S, Israel LL, Bianchessi S, Scanziani E, Lellouche JP, Knoll P, Werner J, Felix K, Grenacher L, Reese T, Kreuter J, Jiménez-González M. Targeted diagnostic magnetic nanoparticles for medical imaging of pancreatic cancer. J Control Release. 2015 Sep 28;214:76-84.
- Zou J, Ostrovsky S, Israel LL, Lellouche JP and Pyykkö I. Targeted Delivery of Contrast Agents to the Tympanic Medial Wall at Minimum Amount and the Efficient Uptake in the Inner Ear through Oval and Round Windows. Austin J Radiol. 2015; 2(6): 1034.
- Israel, L. L., Karimi, F., Bianchessi, S., Scanziani, E., Passoni, L., Matteoli, M., ... Lellouche, J. P. (2015). Surface metal cation doping of maghemite nanoparticles: Modulation of MRI relaxivity features and chelator-free 68Garadiolabelling for dual MRI-PET imaging. Materials Research Express, 2(9), [095009].
- Lellouche E, Israel LL, Bechor M, Attal S, Kurlander E, Asher VA, Dolitzky A, Shaham L, Izraeli S, Lellouche JP, Michaeli S. MagRET Nanoparticles: An Iron Oxide Nanocomposite Platform for Gene Silencing from MicroRNAs to Long Noncoding RNAs. Bioconjug Chem. 2015 Aug 19;26(8):1692-701.
- Israel LL, Lellouche E, Ostrovsky S, Yarmiayev V, Bechor M, Michaeli S, Lellouche JP. Acute in vivo toxicity mitigation of PEI-coated maghemite nanoparticles using controlled oxidation and surface modifications toward siRNA delivery. ACS Appl Mater Interfaces. 2015 Jul 22;7(28):15240-55.
- Israel LL, Kovalenko EI, Boyko AA, Sapozhnikov AM, Rosenberger I, Kreuter J, Passoni L, Lellouche JP. Towards hybrid biocompatible magnetic rHuman serum albumin-based nanoparticles: use of ultra-small (CeLn)3/4+ cation-doped maghemite nanoparticles as functional shell. Nanotechnology. 2015 Jan 30;26(4):045601.
- Israel LL, Lellouche E, Kenett RS, Green O, Michaeli, S, Lellouche JP. Ce3/4+ cation-functionalized maghemite nanoparticles towards siRNA-mediated gene silencing. J. Mater. Chem. B, 2014, 2, 6215.
- Locatelli E, Gil L, Israel LL, Passoni L, Naddaka M, Pucci A, Reese T, Gomez-Vallejo V, Milani P, Matteoli M, Llop J, Lellouche JP, Franchini MC. Biocompatible nanocomposite for PET/MRI hybrid imaging. Int J Nanomedicine. 2012;7:6021-33.
- C. Adams, L. L. Israel, S. Ostrovsky, A. Taylor, H. Poptani, J.-P. Lellouche, & D. Chari, Development of Multifunctional Magnetic Nanoparticles for Genetic Engineering and Tracking of Neural Stem Cells, Adv. Health Care Mater., 2016, 5(7), 841-849
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