Anti-Citrullinated Human Fibrinogen [10E9.3] Antibody
![Anti-Citrullinated Human Fibrinogen [10E9.3] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1548_2001202001265215470.jpg "Anti-Citrullinated Human Fibrinogen [10E9.3] Antibody")
This mouse monoclonal antibody was generated against citrullinated-human fibrinogen and recognizes citrullinated-human fibrinogen.
Highlights:
- Reacts with citrullinated-human fibrinogen
- Does not detect unmodified fibrinogen
- Suitable for ELISA applications
Fibrinogen is a plasma clotting factor composed of three different polypeptide chains (α, β and γ). Under chronic inflammatory conditions, fibrinogen can be acted upon by the enzyme peptidylarginine deiminase 4 (PAD4), converting specific arginine residues to citrulline. Patients with rheumatoid arthritis (RA) produce antibodies that bind citrullinated human fibrinogen. The citrullinated fibrinogen and reactive antibodies form immune complexes in RA patients, and these immune complexes can stimulate macrophages. Recently, it has been discovered that immunizing certain strains of mice with citrullinated human fibrinogen can induce the production of anti-citrullinated human fibrinogen antibodies and the development of arthritis that shares many pathophysiological features of the human disease.
From the laboratory of Ann M. Rothstein, PhD, University of Massachusetts Medical School.
This mouse monoclonal antibody was generated against citrullinated-human fibrinogen and recognizes citrullinated-human fibrinogen.
Highlights:
- Reacts with citrullinated-human fibrinogen
- Does not detect unmodified fibrinogen
- Suitable for ELISA applications
Fibrinogen is a plasma clotting factor composed of three different polypeptide chains (α, β and γ). Under chronic inflammatory conditions, fibrinogen can be acted upon by the enzyme peptidylarginine deiminase 4 (PAD4), converting specific arginine residues to citrulline. Patients with rheumatoid arthritis (RA) produce antibodies that bind citrullinated human fibrinogen. The citrullinated fibrinogen and reactive antibodies form immune complexes in RA patients, and these immune complexes can stimulate macrophages. Recently, it has been discovered that immunizing certain strains of mice with citrullinated human fibrinogen can induce the production of anti-citrullinated human fibrinogen antibodies and the development of arthritis that shares many pathophysiological features of the human disease.
From the laboratory of Ann M. Rothstein, PhD, University of Massachusetts Medical School.
| Product Type: | Antibody |
| Accession ID: | P02671 |
| Isotype: | IgG2b |
| Clonality: | Monoclonal |
| Clone Name: | 10E9.3 |
| Reactivity: | Human |
| Immunogen: | citrullinated human fibrinogen |
| Species Immunized: | Balb/c mice |
| Purification Method: | Protein A-Agarose column |
| Buffer: | 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide |
| Storage: | -20C |
| Shipped: | Cold packs |
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