Anti-Integrin alpha-IIb (ITGA2B) [Tab, 8aB5-9-9-15] Antibody
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This mouse IgG1 monoclonal antibody (Tab) was raised against recombinant human platelets and is specific for human Integrin alpha-IIb subunit.
Highlights:
- Recognizes human Integrin alpha-IIb subunit
- Suitable for Flow Cytometry, Immunohistochemistry and Immunoprecipitation applications
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
From the laboratory of Rodger P. McEver, MD
, Oklahoma Medical Research Foundation.
This mouse IgG1 monoclonal antibody (Tab) was raised against recombinant human platelets and is specific for human Integrin alpha-IIb subunit.
Highlights:
- Recognizes human Integrin alpha-IIb subunit
- Suitable for Flow Cytometry, Immunohistochemistry and Immunoprecipitation applications
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
From the laboratory of Rodger P. McEver, MD , Oklahoma Medical Research Foundation.
| Product Type: | Antibody |
| Alternative Name(s): | Tab |
| Antigen: | Integrin alpha-IIb subunit |
| Accession ID: | P08514 |
| Molecular Weight: | 130 kDa |
| Isotype: | IgG1 |
| Clonality: | Monoclonal |
| Clone Name: | Tab, 8aB5-9-9-15 |
| Reactivity: | Human |
| Immunogen: | Human platelets |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | Flow cytometry, IHC, IP |
| Storage: | -20C |
| Shipped: | Cold packs |
- McEver RP, Baenziger NL, Majerus PW. Isolation and quantitation of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibody. J Clin Invest. 1980 Dec;66(6):1311-8. PubMed PMID: 6449521
- McEver RP, Bennett EM, Martin MN. Identification of two structurally and functionally distinct sites on human platelet membrane glycoprotein IIb-IIIa using monoclonal antibodies. J Biol Chem. 1983 Apr 25;258(8):5269-75. PubMed PMID: 6220015.
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