Anti-Ceacam 1 [2456/2457] Antibody
![Anti-Ceacam 1, [2456/2457] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1611_2001202001265416100.jpg "Anti-Ceacam 1 [2456/2457] Antibody")
This rabbit polyclonal antibody was generated against carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)-His-tagged purified protein from HEK293 transfected cells, protein fully glycosylated and is specific for mouse CEACAM1.
Highlights:
- Specific for mouse CEACAM1; Does not react with other species
- Reacts with N-terminal domain
- Suitable for Western Blot, Immunoprecipitation, Immunofluorescence and Immunohistochemistry applications
CEACAM1 (biliary glycoprotein) is a cell adhesion molecule with reduced expression in early phases of CRC development and thus functions as a tumor growth inhibitor. This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19 and the mouse CEACAM1 gene is located on mouse chr. 7. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cellcell adhesion molecule detected on leukocytes, epithelia, and endothelia. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.
From the laboratory of Nicole Beauchemin, PhD, McGill University.
This rabbit polyclonal antibody was generated against carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)-His-tagged purified protein from HEK293 transfected cells, protein fully glycosylated and is specific for mouse CEACAM1.
Highlights:
- Specific for mouse CEACAM1; Does not react with other species
- Reacts with N-terminal domain
- Suitable for Western Blot, Immunoprecipitation, Immunofluorescence and Immunohistochemistry applications
CEACAM1 (biliary glycoprotein) is a cell adhesion molecule with reduced expression in early phases of CRC development and thus functions as a tumor growth inhibitor. This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19 and the mouse CEACAM1 gene is located on mouse chr. 7. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cellcell adhesion molecule detected on leukocytes, epithelia, and endothelia. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.
From the laboratory of Nicole Beauchemin, PhD, McGill University.
| Product Type: | Antibody |
| Antigen: | CEACAM1 |
| Accession ID: | P13688 |
| Molecular Weight: |
Native protein: CEACAM1-L (58 kDa), CEACAM1-S (54 kDa) Glycosylated proteins so MW depends on the tissue: colon (120 kDa), liver (110 kDa), neutrophils (160 kDa) |
| Clonality: | Polyclonal |
| Clone Name: | 2456/2457 |
| Reactivity: | Mouse |
| Immunogen: | CEACAM1-His-tagged purified protein from HEK293 transfected cells, protein fully glycosylated |
| Species Immunized: | Rabbit |
| Epitope: | N-terminal domain mainly |
| Buffer: | Serum |
| Tested Applications: | WB (1:3000), IP (10 ul of Ab for IP of CEACAM1 from 1 mg of total lysate protein from transfected cells), IF (1:500-1:800), IHC (1:250-1:500) |
| Storage: | -80C |
| Shipped: | Cold Packs (Domestic, Overnight); Dry Ice (International) |
- Houde C, Roy S, Leung N, Nicholson DW, Beauchemin N. The cell adhesion molecule CEACAM1-L is a substrate of caspase-3-mediated cleavage in apoptotic mouse intestinal cells. J Biol Chem. 2003 May 9;278(19):16929-35. Epub 2003 Mar 11.
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