Anti-Complement C3b/C4b (CR1) [7G9] Antibody
![Anti-Complement C3b/C4b (CR1) [7G9] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1616_2001202001265416150.jpg "Anti-Complement C3b/C4b (CR1) [7G9] Antibody")
This mouse IgG2a monoclonal antibody was generated against human complement receptor 1 (CR1; also known as C3b/C4b receptor or CD35) and recognizes human CR1.
Highlights:
- Reacts with human CR1
- Recognizes human CR1 expressed on red cells and other cells
- Suitable for ELISA and Immunofluorescence applications
The complement system consists of a number of small proteins found in the blood, generally synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. The CR1 gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The protein is involved in cellular binding to particles and immune complexes that have activated complement. Decreases in protein expression or mutations in the gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis.
From the laboratory of Ronald P. Taylor, PhD, University of Virginia.
This mouse IgG2a monoclonal antibody was generated against human complement receptor 1 (CR1; also known as C3b/C4b receptor or CD35) and recognizes human CR1.
Highlights:
- Reacts with human CR1
- Recognizes human CR1 expressed on red cells and other cells
- Suitable for ELISA and Immunofluorescence applications
The complement system consists of a number of small proteins found in the blood, generally synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. The CR1 gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The protein is involved in cellular binding to particles and immune complexes that have activated complement. Decreases in protein expression or mutations in the gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis.
From the laboratory of Ronald P. Taylor, PhD, University of Virginia.
| Product Type: | Antibody |
| Antigen: | Complement receptor 1 (CR1; also known as C3b/C4b receptor or CD35) |
| Accession ID: | P01024 |
| Isotype: | IgG2a |
| Clonality: | Monoclonal |
| Clone Name: | 7G9 |
| Reactivity: | Human |
| Immunogen: | Human complement receptor 1 |
| Species Immunized: | Mouse |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | ELISA, IF |
| Storage: | -20C |
| Shipped: | Cold Packs |
- Ferguson PJ, Reist CJ, Martin EN, Johnson C, Greene KL, Kuhn S, Niebur J, Emlen W, Taylor RP. Antigen-based heteropolymers. A potential therapy for binding and clearing autoantibodies via erythrocyte CR1. Arthritis Rheum. 1995 Feb;38(2):190-200. PubMed PMID: 7848309.
- Hahn CS, French OG, Foley P, Martin EN, Taylor RP. Bispecific monoclonal antibodies mediate binding of dengue virus to erythrocytes in a monkey model of passive viremia. J Immunol. 2001 Jan 15;166(2):1057-65. PubMed PMID: 11145685.
- Craig ML, Waitumbi JN, Taylor RP. Processing of C3b-opsonized immune complexes bound to non-complement receptor 1 (CR1) sites on red cells: phagocytosis, transfer, and associations with CR1. J Immunol. 2005 Mar 1;174(5):3059-66. PubMed PMID: 15728520.
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