Anti-Cadherin-1 [19A11] Antibody
![Anti-Cadherin-1 [19A11] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1618_2001202001265416170.jpg "Anti-Cadherin-1 [19A11] Antibody")
This mouse IgG1 monoclonal antibody was generated against human E-cadherin (partial, amino acids 155-707) and recognizes human and dog cadherin-1 (CDH1).
Highlights:
- Reacts with human and dog CDH1
- Can bind human E-cadherin protein on the cell surface and activate the protein to stimulate strong cell-cell adhesion between tumor cells
- Suitable for ELISA and Immunofluorescence, Immunocytochemistry, Western Blot and Immunoprecipitation applications
Cadherin-1 is a member of the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Mutations in this gene have been shown to associated with gastric, breast, colorectal, thyroid, and ovarian cancers.
From the laboratory of Barry M. Gumbiner, PhD, University of Virginia.
This mouse IgG1 monoclonal antibody was generated against human E-cadherin (partial, amino acids 155-707) and recognizes human and dog cadherin-1 (CDH1).
Highlights:
- Reacts with human and dog CDH1
- Can bind human E-cadherin protein on the cell surface and activate the protein to stimulate strong cell-cell adhesion between tumor cells
- Suitable for ELISA and Immunofluorescence, Immunocytochemistry, Western Blot and Immunoprecipitation applications
Cadherin-1 is a member of the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Mutations in this gene have been shown to associated with gastric, breast, colorectal, thyroid, and ovarian cancers.
From the laboratory of Barry M. Gumbiner, PhD, University of Virginia.
| Product Type: | Antibody |
| Alternative Name(s): | CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin, CD_antigen: CD324 |
| Accession ID: | P12830 |
| Antigen: | Cadherin-1 |
| Isotype: | IgG1 |
| Clonality: | Monoclonal |
| Clone Name: | 19A11 |
| Reactivity: | Human and dog |
| Immunogen: | Human E-cadherin (partial, amino acids 155-707) |
| Species Immunized: | Mouse |
| Buffer: | 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB, ELISA, IF(ICC), IP |
| Storage: | -20C |
| Shipped: | Cold Packs |
- Petrova YI, Spano MM, Gumbiner BM. Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion. Mol Biol Cell. 2012 Jun;23(11):2092-108.
- Wiesner DL, Merkhofer RM, Ober C, Kujoth GC, Niu M, Keller NP, Gern JE, Brockman-Schneider RA, Evans MD, Jackson DJ, Warner T, Jarjour NN, Esnault SJ, Feldman MB, Freeman M, Mou H, Vyas JM, Klein BS. Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation. Cell Host Microbe. 2020 Apr 8;27(4):614-628.e6. View article
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