Anti-Aconitase (ACO1/IRP1) Antibody
This rabbit polyclonal antibody was generated against recombinant human iron regulatory protein 1 (IRP1) and recognizes human and mouse IRP1 .
Highlights:
- Reacts with human and mouse, full-length IRP1
- Suitable for Western Blot and Immunoprecipitation applications
IRP1 stands for “iron regulatory protein 1”. It is encoded by the ACO1 gene (aconitase 1). IRP1 is a soluble protein and an iron sensor. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate.
From the laboratory of Kostas Pantopoulos, PhD, McGill University.
This rabbit polyclonal antibody was generated against recombinant human iron regulatory protein 1 (IRP1) and recognizes human and mouse IRP1 .
Highlights:
- Reacts with human and mouse, full-length IRP1
- Suitable for Western Blot and Immunoprecipitation applications
IRP1 stands for “iron regulatory protein 1”. It is encoded by the ACO1 gene (aconitase 1). IRP1 is a soluble protein and an iron sensor. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate.
From the laboratory of Kostas Pantopoulos, PhD, McGill University.
Specifications
| Product Type: | Antibody |
| Accession ID: | P21399 |
| Antigen: | Human IRP1 |
| Molecular Weight: | 100 kDa |
| Clonality: | Polyclonal |
| Reactivity: | Human and Mouse |
| Immunogen: | Recombinant human IRP1 |
| Species Immunized: | Rabbit |
| Epitope: | Full length IRP1 |
| Purification Method: | Serum |
| Buffer: | Serum with 0.05% sodium azide |
| Tested Applications: | WB (1:2000) and IP |
| Storage: | -80C |
| Shipped: | Cold Packs (Domestic, Overnight); Dry Ice (International) |
Provider
From the laboratory of Kostas Pantopoulos, PhD, McGill University.
References
- Fillebeen C, Chahine D, Caltagirone A, Segal P, Pantopoulos K. A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation. Mol Cell Biol. 2003 Oct;23(19):6973-81.
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