Canine Osteosarcoma Cell Line (OSCA-29)
OSCA-29 is a canine osteosarcoma cell line derived from a primary tumor in the right front leg of a 6-year old female Rottweiler.
Highlights:
- Gene expression profile is consistent with that observed in more aggressive molecular phenotype of osteosarcoma
- Tumor also showed aggressive behavior in the original dog patient, eventually metastasizing to the brain
Osteosarcomas are aggressive malignant neoplasia that arise from primitive transformed cells of mesenchymal origin (and thus a sarcoma) and exhibit osteoblastic differentiation and produce malignant osteoid.
From the laboratory of Jaime F. Modiano, VMD, PhD, University Minnesota, Twin Cities.
OSCA-29 is a canine osteosarcoma cell line derived from a primary tumor in the right front leg of a 6-year old female Rottweiler.
Highlights:
- Gene expression profile is consistent with that observed in more aggressive molecular phenotype of osteosarcoma
- Tumor also showed aggressive behavior in the original dog patient, eventually metastasizing to the brain
Osteosarcomas are aggressive malignant neoplasia that arise from primitive transformed cells of mesenchymal origin (and thus a sarcoma) and exhibit osteoblastic differentiation and produce malignant osteoid.
From the laboratory of Jaime F. Modiano, VMD, PhD, University Minnesota, Twin Cities.
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Specifications
| Product Type: | Cell Line |
| Name: | OSCA-29 |
| Cell Type: | Osteosarcoma |
| Accession ID: | CVCL_L384 |
| Organism: | Dog |
| Source: | Bone (R. humerus) |
| Morphology: | Spindle |
| Biosafety Level: | 2 |
| Subculturing: | Doubling time approx. 1 day |
| Growth Conditions: | DMEM, 10mM HEPES, 10% FBS, 100ug/mL Primocin |
| Cryopreservation: | 90%FBS/10% DMSO |
| Mycoplasma Tested: | Yes |
| Storage: | Liquid nitrogen |
| Shipped: | Dry Ice |
Documentation
Provider
From the laboratory of Jaime F. Modiano, VMD, PhD, University Minnesota, Twin Cities.
References
- Scott MC, Sarver AL, Gavin KJ, Thayanithy V, Getzy DM, Newman RA, Cutter GR, Lindblad-Toh K, Kisseberth WC, Hunter LE, Subramanian S, Breen M, Modiano JF. Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach. Bone. 2011 Sep;49(3):356-67.
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