Anti-Guinea pig GnRH [TF60] Antibody
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This rabbit polyclonal antibody was generated against a peptide corresponding to Guinea pig Gonadotropin releasing hormone (GnRH) and recognizes Guinea pig GnRH.
Highlights:
- Reacts with Guinea pig GnRH
- No cross-reactivity with mammalian GnRH
- Suitable for Radioimmuno assay (RIA) and Immunocytochemitry applications
Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.
From the laboratory of Stacia A. Sower, PhD, University of New Hampshire.
This rabbit polyclonal antibody was generated against a peptide corresponding to Guinea pig Gonadotropin releasing hormone (GnRH) and recognizes Guinea pig GnRH.
Highlights:
- Reacts with Guinea pig GnRH
- No cross-reactivity with mammalian GnRH
- Suitable for Radioimmuno assay (RIA) and Immunocytochemitry applications
Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.
From the laboratory of Stacia A. Sower, PhD, University of New Hampshire.
| Product Type: | Antibody |
| Name: | Guinea pig GnRH [TF60] Antibody |
| Antigen: | Extended Guinea pig GnRH |
| Accession ID: | P01148 |
| Clonality: | Polyclonal |
| Immunogen: | Extended Guinea pig GnRH (pGlu-Tyr-Trp-Ser-Tyr-Gly-Val-Arg-Pro-Gly-Lys) Available Here |
| Species Immunized: | Rabbit |
| Buffer: | Whole serum |
| Storage: | -80C |
| Shipped: | Cold Packs (Domestic, Overnight); Dry Ice (International) |
- DANIELLE GROVE-STRAWSER, STACIA A. SOWER, PAUL M. RONSHEIM, JANE B. CONNOLLY, CARI G. BOURN, AND BEVERLY S. RUBIN. 2002. Guinea Pig GnRH: Localization and Physiological Activity Reveal That It, Not Mammalian GnRH, Is the Major Neuroendocrine Form in Guinea Pigs. Endocrinology 143 (5): 1602-1612.
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